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1

Substrate and inhibitor specificities differ between human cytosolic and mitochondrial thioredoxin reductases: Implications for development of specific inhibitors

Oliver Rackham, Anne-Marie J. Shearwood, Ross Thyer, Elyshia McNamara, Stefan M.K. Davies, Bernard A. Callus, Antonio Miranda-Vizuete, Susan J. Berners-Price, Qing Cheng, Elias S.J. Arnér, Aleksandra

Journal:

Free Radical Biology and Medicine

Year:

2011

Language:

english

File:

PDF, 993 KB

english, 2011

2

Physiological functions of thioredoxin and thioredoxin reductase

Elias S. J. Arnér, Arne Holmgren

Journal:

Year:

2000

Language:

english

File:

PDF, 463 KB

english, 2000

3

The thioredoxin system in cancer

Elias S.J. Arnér, Arne Holmgren

Journal:

Seminars in Cancer Biology

Year:

2006

Language:

english

File:

PDF, 126 KB

english, 2006

4

The thioredoxin system in cancer—introduction to a thematic volume of Seminars in Cancer Biology

Elias S.J. Arnér, Arne Holmgren

Journal:

Seminars in Cancer Biology

Year:

2006

Language:

english

File:

PDF, 140 KB

english, 2006

5

Reactive oxygen species, antioxidants, and the mammalian thioredoxin system

Jonas Nordberg, Elias S.J. Arnér

Journal:

Free Radical Biology and Medicine

Year:

2001

Language:

english

File:

PDF, 337 KB

english, 2001

6

Interactions of Quinones with Thioredoxin Reductase

Cenas, Narimantas, Nivinskas, Henrikas, Anusevicius, Zilvinas, Sarlauskas, Jonas, Lederer, Florence, Arnér, Elias S. J.

Journal:

Journal of Biological Chemistry

Year:

2004

Language:

english

File:

PDF, 254 KB

english, 2004

7

Sepp1UF forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1

Kurokawa, Suguru, Eriksson, Sofi, Rose, Kristie L., Wu, Sen, Motley, Amy K., Hill, Salisha, Winfrey, Virginia P., McDonald, W. Hayes, Capecchi, Mario R., Atkins, John F., Arnér, Elias S.J., Hill, Kris

Journal:

Free Radical Biology and Medicine

Year:

2014

Language:

english

File:

PDF, 2.10 MB

english, 2014

8

[Advances in Cancer Research] Selenium and Selenoproteins in Cancer Volume 136 || Targeting the Selenoprotein Thioredoxin Reductase 1 for Anticancer Therapy

Arnér, Elias S.J.

Year:

2017

Language:

english

File:

PDF, 384 KB

english, 2017

9

Selenium and selenoproteins in (redox) signaling, diseases, and animal models - 200 year anniversary issue

Brigelius-Flohé, Regina, Arnér, Elias S.J.

Journal:

Free Radical Biology and Medicine

Year:

2018

Language:

english

File:

PDF, 371 KB

english, 2018

10

Oxidative Stress || Perspectives of TrxR1-based cancer therapies

Arnér, Elias S.J.

Year:

2020

Language:

english

File:

PDF, 823 KB

english, 2020

11

Selenolthiol and Dithiol C-Terminal Tetrapeptide Motifs for One-Step Purification and Labeling of Recombinant Proteins Produced in E. coli

Qing Cheng, Linda Johansson, Jan-Olov Thorell, Anna Fredriksson, Erik Samén, Sharon Stone-Elander, Elias S. J. Arnér

Journal:

Year:

2006

Language:

english

File:

PDF, 263 KB

english, 2006

12

ChemInform Abstract: Human Protein Atlas of Redox Systems — What Can Be Learnt?

Pascal Dammeyer, Elias S. J. Arner

Journal:

Year:

2011

File:

PDF, 18 KB

2011

13

Abstracts of poster presentations

A. B. Agostinho, F. Rosi, A. Tabucchi, F. Carlucci, M. Pizzichini, Elias S. J. Arnér, Staffan Eriksson, J. Barankiewicz, H. Trembacz, L. Zwierzchowski, A. M. Bergman, V. W. T. Ruiz van Haperen, G. Vee

Journal:

International Journal of Clinical Pharmacy

Year:

1993

Language:

english

File:

PDF, 1.89 MB

english, 1993

14

A mouse model for in vivo tracking of the major dust mite allergen Der p 2 after inhalation

Linda Johansson, Linda Svensson, Ulrika Bergström, Gunilla Jacobsson-Ekman, Elias S. J. Arnér, Marianne van Hage, Anders Bucht, Guro Gafvelin

Journal:

Year:

2005

Language:

english

File:

PDF, 535 KB

english, 2005

15

Exploiting the 21st amino acid—purifying and labeling proteins by selenolate targeting

Johansson, Linda, Chen, Chunying, Thorell, Jan-Olov, Fredriksson, Anna, Stone-Elander, Sharon, Gafvelin, Guro, Arnér, Elias S J

Journal:

Year:

2004

Language:

english

File:

PDF, 367 KB

english, 2004

16

Tagging recombinant proteins with a Sel-tag for purification, labeling with electrophilic compounds or radiolabeling with 11C

Cheng, Qing, Stone-Elander, Sharon, Arnér, Elias S J

Journal:

Nature Protocols

Year:

2006

Language:

english

File:

PDF, 342 KB

english, 2006

17

Superoxide production by dinitrophenyl- derivatized thioredoxin reductase - a model for the mechanism and correlation to immunostimulation by dinitrohalobenzenes

Elias S.J. Arnér

Journal:

Year:

1999

Language:

english

File:

PDF, 99 KB

english, 1999

18

Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase

Tomas Nordman, Ling Xia, Linda Björkhem-Bergman, Anastassios Damdimopoulos, Ivan Nalvarte, Elias S. J. Arnér, Giannis Spyrou, Lennart C. Eriksson, Mikael Björnstedt, Jerker M. Olsson

Journal:

Year:

2003

Language:

english

File:

PDF, 43 KB

english, 2003

19

Mammalian deoxyribonucleoside kinases

Elias S.J. Arnér, Staffan Eriksson

Journal:

Pharmacology & Therapeutics

Year:

1995

Language:

english

File:

PDF, 3.30 MB

english, 1995

20

The human thioredoxin reductase-1 splice variant TXNRD1_v3 is an atypical inducer of cytoplasmic filaments and cell membrane filopodia

Pauliina E. Damdimopoulou, Antonio Miranda-Vizuete, Elias S.J. Arnér, Jan-Åke Gustafsson, Anastasios E. Damdimopoulos

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2009

Language:

english

File:

PDF, 755 KB

english, 2009

21

The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidation

Andrew G. Cox, Kristin K. Brown, Elias S.J. Arner, Mark B. Hampton

Journal:

Biochemical Pharmacology

Year:

2008

Language:

english

File:

PDF, 1.16 MB

english, 2008

22

Pyrroloquinoline quinone modulates the kinetic parameters of the mammalian selenoprotein thioredoxin reductase 1 and is an inhibitor of glutathione reductase

Jianqiang Xu, Elias S.J. Arnér

Journal:

Biochemical Pharmacology

Year:

2012

Language:

english

File:

PDF, 599 KB

english, 2012

23

Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds

Anne-Barbara Witte, Karin Anestål, Elin Jerremalm, Hans Ehrsson, Elias S.J. Arnér

Journal:

Free Radical Biology and Medicine

Year:

2005

Language:

english

File:

PDF, 307 KB

english, 2005

24

Studies of an active site mutant of the selenoprotein thioredoxin reductase: The Ser-Cys-Cys-Ser motif of the insect orthologue is not sufficient to replace the Cys-Sec dyad in the mammalian enzyme

Linda Johansson, L. David Arscott, David P. Ballou, Charles H. Williams Jr., Elias S.J. Arnér

Journal:

Free Radical Biology and Medicine

Year:

2006

Language:

english

File:

PDF, 266 KB

english, 2006

25

Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates

Kristin K. Brown, Sofi E. Eriksson, Elias S.J. Arnér, Mark B. Hampton

Journal:

Free Radical Biology and Medicine

Year:

2008

Language:

english

File:

PDF, 996 KB

english, 2008

26

Highly active dimeric and low-activity tetrameric forms of selenium-containing rat thioredoxin reductase 1

Olle Rengby, Qing Cheng, Marie Vahter, Hans Jörnvall, Elias S.J. Arnér

Journal:

Free Radical Biology and Medicine

Year:

2009

Language:

english

File:

PDF, 601 KB

english, 2009

27

High levels of thioredoxin reductase 1 modulate drug-specific cytotoxic efficacy

Sofi E. Eriksson, Stefanie Prast-Nielsen, Emilie Flaberg, Laszlo Szekely, Elias S.J. Arnér

Journal:

Free Radical Biology and Medicine

Year:

2009

Language:

english

File:

PDF, 1.29 MB

english, 2009

28

Noble metal targeting of thioredoxin reductase — covalent complexes with thioredoxin and thioredoxin-related protein of 14 kDa triggered by cisplatin

Stefanie Prast-Nielsen, Marcus Cebula, Irina Pader, Elias S.J. Arnér

Journal:

Free Radical Biology and Medicine

Year:

2010

Language:

english

File:

PDF, 1.42 MB

english, 2010

29

The Interactions of Thioredoxin Reductase with Quinones and Acrolein: Covalent Adducts and Stimulation of NADPH Oxidase Activity

Charles R Myers, Qing Cheng, Judith M Myers, William E Antholine, Elias S.J. Arnér

Journal:

Free Radical Biology and Medicine

Year:

2010

Language:

english

File:

PDF, 415 KB

english, 2010

30

Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay

Stefanie Prast-Nielsen, Thomas S. Dexheimer, Lena Schultz, William C. Stafford, Qing Cheng, Jianqiang Xu, Ajit Jadhav, Elias S.J. Arnér, Anton Simeonov

Journal:

Free Radical Biology and Medicine

Year:

2011

Language:

english

File:

PDF, 1.18 MB

english, 2011

31

Thioredoxin Reductase Inhibition Induces Nrf2mediated Antioxidant Responses in Murine Transformed Clara Cells

Morgan L. Locy, Lynette K. Rogers, Leif D. Nelin, Justin R. Prigge, Edward E. Schmidt, Elias S.J. Arnér, Trent E. Tipple

Journal:

Free Radical Biology and Medicine

Year:

2011

Language:

english

File:

PDF, 68 KB

english, 2011

32

Hepatocyte DNA replication in growing liver requires either glutathione or a single allele of txnrd1

Justin R. Prigge, Sofi Eriksson, Sonya V. Iverson, Tesia A. Meade, Mario R. Capecchi, Elias S.J. Arnér, Edward E. Schmidt

Journal:

Free Radical Biology and Medicine

Year:

2012

Language:

english

File:

PDF, 1.05 MB

english, 2012

33

Red wine triggers cell death and thioredoxin reductase inhibition: Effects beyond resveratrol and SIRT1

Karolina Wallenborg, Pinelopi Vlachos, Sofi Eriksson, Lukas Huijbregts, Elias S.J. Arnér, Bertrand Joseph, Ola Hermanson

Journal:

Experimental Cell Research

Year:

2009

Language:

english

File:

PDF, 2.21 MB

english, 2009

34

Selenoproteins—What unique properties can arise with selenocysteine in place of cysteine?

Elias S.J. Arnér

Journal:

Experimental Cell Research

Year:

2010

Language:

english

File:

PDF, 240 KB

english, 2010

35

Analysis of the inhibition of mammalian thioredoxin, thioredoxin reductase, and glutaredoxin by cis-diamminedichloroplatinum (II) and its major metabolite, the glutathione-platinum complex

Elias S.J. Arnér, Hajime Nakamura, Tetsuro Sasada, Junji Yodoi, Arne Holmgren, Giannis Spyrou

Journal:

Free Radical Biology and Medicine

Year:

2001

Language:

english

File:

PDF, 141 KB

english, 2001

36

Phosphorylation of 2-chlorodeoxyadenosine (CdA) in extracts of peripheral blood mononuclear cells of leukaemic patients

Elias S. J. Arner, Tatjana Spasokoukotskaja, Gunnar Juliusson, Jan Liliemark, Staffan Eriksson

Journal:

British Journal of Haematology

Year:

1994

Language:

english

File:

PDF, 360 KB

english, 1994

37

Efficient Reduction of Lipoamide and Lipoic Acid by Mammalian Thioredoxin Reductase

Elias S.J. Arnér, Jonas Nordberg, Arne Holmgren

Journal:

Biochemical and Biophysical Research Communications

Year:

1996

Language:

english

File:

PDF, 114 KB

english, 1996

38

High-level expression in Escherichia coli of selenocysteine-containing rat thioredoxin reductase utilizing gene fusions with engineered bacterial-type SECIS elements and co-expression with the selA, selB and selC genes

Elias S.J Arnér, Hakan Sarioglu, Friedrich Lottspeich, Arne Holmgren, August Böck

Journal:

Journal of Molecular Biology

Year:

1999

Language:

english

File:

PDF, 325 KB

english, 1999

39

Maximal flux responses after multiple challenges with vasopressin

Meryl S. Rubin, Christine F. King, Jocelyn D. Weissman, Dan Gershator, Elias Arner, Sandra K. Masur

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1984

Language:

english

File:

PDF, 710 KB

english, 1984

40

Selective assays for thymidine kinase 1 and 2 and deoxycytidine kinase and their activities in extracts from human cells and tissues

Elias S.J. Arnér, Tatjana Spasokoukotskaja, Staffan Eriksson

Journal:

Biochemical and Biophysical Research Communications

Year:

1992

Language:

english

File:

PDF, 538 KB

english, 1992

41

Deoxycytidine kinase is constitutively expressed in human lymphocytes: Consequences for compartmentation effects, unscheduled dna synthesis, and viral replication in resting cells

Elias S.J. Arnér, Martin Flygar, Christina Bohman, Birgitta Wallstrom, Staffan Eriksson

Journal:

Experimental Cell Research

Year:

1988

Language:

english

File:

PDF, 615 KB

english, 1988

42

Selenocysteine in proteins—properties and biotechnological use

Linda Johansson, Guro Gafvelin, Elias S.J. Arnér

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2005

Language:

english

File:

PDF, 248 KB

english, 2005

43

Focus on mammalian thioredoxin reductases — Important selenoproteins with versatile functions

Elias S.J. Arnér

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2009

Language:

english

File:

PDF, 853 KB

english, 2009

44

Special issue on selenoprotein expression and function

Christopher Horst Lillig, Elias Arnér

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2009

Language:

english

File:

PDF, 144 KB

english, 2009

45

Human Protein Atlas of redox systems — What can be learnt?

Pascal Dammeyer, Elias S.J. Arnér

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2011

Language:

english

File:

PDF, 14.61 MB

english, 2011

46

Expression of selenocysteine-containing glutathione S-transferase in Escherichia coli

Zhihua Jiang, Elias S.J. Arnér, Ying Mu, Linda Johansson, Jinming Shi, Siqi Zhao, Shujun Liu, Ruiying Wang, Tianzhu Zhang, Ganglin Yan, Junqiu Liu, Jiacong Shen, Guimin Luo

Journal:

Biochemical and Biophysical Research Communications

Year:

2004

Language:

english

File:

PDF, 432 KB

english, 2004

47

Evidence for intriguingly complex transcription of human thioredoxin reductase 1

Anna-Klara Rundlöf, Magnus Janard, Antonio Miranda-Vizuete, Elias S.J. Arnér

Journal:

Free Radical Biology and Medicine

Year:

2004

Language:

english

File:

PDF, 652 KB

english, 2004

48

[Methods in Enzymology] Oxidants and Antioxidants Part B Volume 300 || Preparation and assay of mammalian thioredoxin and thioredoxin reductase

Arnér, Elias S.J.

Year:

1999

Language:

english

File:

PDF, 759 KB

english, 1999

49

Redox activation of Fe(III)–thiosemicarbazones and Fe(III)–bleomycin by thioredoxin reductase: specificity of enzymatic redox centers and analysis of reactive species formation by ESR spin trapping

Myers, Judith M., Cheng, Qing, Antholine, William E., Kalyanaraman, Balaraman, Filipovska, Aleksandra, Arnér, Elias S.J., Myers, Charles R.

Journal:

Free Radical Biology and Medicine

Year:

2013

Language:

english

File:

PDF, 1.47 MB

english, 2013

50

Serum thioredoxin reductase levels increase in response to chemically induced acute liver injury

Sun, Kang, Eriksson, Sofi E., Tan, Yanping, Zhang, Le, Arnér, Elias S.J., Zhang, Jinsong

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2014

Language:

english

File:

PDF, 1.05 MB

english, 2014

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